玛丽·卢·瓦拉诺博士

研究抽象

Neuronal survival and development.

Modification of synaptic neurotransmission at glutamatergic synapses and activation of Ca²⁺-dependent second messenger systems contribute to the processes of learning and memory, neuronal survival and differentiation. 除了, these systems play important roles in the neuronal dysfunction that is observed following stroke and ischemia, focal epilepsies and Alzheimer’s disease. Our research program was previously focused on analysis of the expression and functional responsiveness of distinct excitatory amino acid receptors (NMDA subtypes), modulation of responses by Ca⁺²-dependent protein kinases, and examination of the roles of these receptors and kinases in neuronal survival and differentiation.

*Note that I have transitioned from research to medical education and my laboratory is no longer functional. I am available to discuss these research idea with interested students, staff, and colleagues.

选定的出版物

Adams AC, Kyle M, Beaman-Hall CM, 摩纳哥季军; Cullen M, Vallano毫升. Microglia in Glia-Neuron Co-cultures Exhibit Robust Phagocytic Activity Without Concomitant Inflammation or Cytotoxicity. 细胞Mol神经生物学. 2015年10月,35 (7):961 - 75. doi: 10.1007/s10571-015-0191-9. Epub 2015年4月18日.PMID: 25894384

Riordan MA, Kyle M, Dedeo C, Villwock MR, Bauer M, Vallano毫升， Deshaies EM. Mild exercise reduces cerebral vasospasm after aneurysm subarachnoid hemorrhage: a retrospective clinical study and correlation with laboratory investigation. 神经科杂志. 2015;120:55-61. doi: 10.1007/978-3-319-04981-6_10.PMID: 25366600

嘉宝, Beaman-Hall CM, Mathur A, Vallano毫升. Reduced blockade by extracellular Mg(2+) is permissive to NMDA receptor activation in cerebellar granule neurons that model a migratory phenotype. J Neurochem. 2010 Jul;114(1):191-202. doi: 10.1111/j.1471-4159.2010.06746.x. Epub 2010年4月9日.PMID: 20403073

Bui CJ, McGann AC, Middleton FA, Beaman-Hall CM, Vallano毫升. Transcriptional profiling of depolarization-dependent phenotypic alterations in primary cultures of developing granule neurons. 大脑Res. 2006 Nov 13;1119(1):13-25. Epub 2006年9月20日.PMID: 16989786

嘉宝, Vallano毫升. Structural properties of the NMDA receptor and the design of neuroprotective therapies. Mini Rev Med Chem. 2006年7月,6 (7):805 - 15. 审查.PMID: 16842130

Vallano毫升, Beaman-Hall CM, Bui CJ, Middleton FA. Depolarization and Ca(2+) down regulate CB1 receptors and CB1-mediated signaling in cerebellar granule neurons. 神经药理学. 2006, (6): 651 - 60. 2006年1月18日.PMID: 16412482

摩纳哥季军; Vallano毫升. Roscovitine triggers excitotoxicity in cultured granule neurons by enhancing glutamate release. 摩尔杂志. 2005 Nov;68(5):1331-42. 2005年7月28日.PMID: 16051748

Tremper-Wells B, Vallano毫升. Nuclear calpain regulates Ca2+-dependent signaling via proteolysis of nuclear Ca2+/calmodulin-dependent protein kinase type IV in cultured neurons. 生物化学. 2005 Jan 21;280(3):2165-75. Epub 2004 11月10日.PMID: 15537635

摩纳哥季军; Vallano毫升. Role of protein kinases in neurodegenerative disease: cyclin-dependent kinases in Alzheimer's disease. 前面Biosci. 2005年1月1日;10:143-59. 2005年1月1日印刷. 审查.PMID: 15574357

Choi JY, Beaman-Hall CM, Vallano毫升. Granule neurons in cerebellum express distinct splice variants of the inositol trisphosphate receptor that are modulated by calcium. Am J Physiol Cell Physiol. 2004 Oct;287(4):C971-80. 2004年6月9日.PMID: 15189817

摩纳哥季军; Beaman-Hall CM, Mathur A, Vallano毫升. Roscovitine, olomoucine, purvalanol: inducers of apoptosis in maturing cerebellar granule neurons. 生物化学杂志. 2004 May 15;67(10):1947-64.PMID: 15130771