Christopher Turner, PhD

研究抽象

摘要

The dynamic adhesion of cells to their surrounding extracellular matrix provides many of the environmental cues necessary for controlling cell migration and cell shape, 生存, proliferation and differentiation. These fundamental events regulate an organism’s normal development, maintenance and recovery from injury and infection. Defects in the signaling pathways associated with cell adhesion provide the basis for cell transformation and cancer cell metastasis, various developmental defects and cardiovascular disease.

My lab uses a multi-faceted approach combining biochemistry, cell and molecular biology and various high-end microscopy techniques along with mouse knockout and tumor models to determine the molecular organization of the proteins that are involved in cell adhesion and thereby understand how they each contribute to cell behavior in vivo. We are particularly interested in characterizing the function of the molecular scaffold/adapter proteins Paxillin and it's close relative Hic-5 during tumor cell migration and invasion. We have found that these multi-domain proteins bind numerous structural and signaling proteins including kinases, phosphatases and Rho family GTPase regulators and effectors. We hypothesize that it is through these various interactions that the cell coordinates intracellular signaling and cytoskeletal reorganization to regulate cell adhesion, migration and tumor invasion.

选择引用

特纳,C.E., (2000) Paxillin and focal adhesion signaling. 自然细胞生物学., 2 E231-6.

布朗,米.C. 特纳，C.E. (2004) Paxillin-Adapting to change. 杂志. 转速. 84, 1315-1339.

迪肯,N.O. 和特纳. C.E. (2011) Paxillin and Hic-5 cooperate to regulate breast cancer cell plasticity, invasion and metastasis. 摩尔. 生物细胞 22 327-341.

迪肯,N.O. 特纳，C.E. (2014) Paxillin interacts with and inhibits HDAC6 in normal and malignant 细胞s to regulate microtubule acetylation, Golgi structural integrity and polarized migration J. 细胞生物. 206 395-413.

杜布瓦F.， K. 特纳，C.E. (2017) Paxillin Regulates 细胞 Polarization and Anterograde Vesicle Trafficking during 细胞 Migration. 摩尔. 医学杂志. 细胞 28 3815-3831.

Goreczny G.J.福赛斯，我. 特纳，C.E. (2018) Hic-5 Regulates Fibrillar Adhesion Formation to Control Tumor Stromal Matrix Remodeling through Interaction with Tensin 1. 致癌基因 37 1699-1713.

Gulvady,.杜波依斯，F.纽约州迪肯市.O.格列兹尼，G.J. 特纳，C.E. (2018) Hic-5 Expression is a Major Indicator of Cancer 细胞 Morphology, Migration and Plasticity in Three-Dimensional Matrices. 摩尔. 医学杂志. 细胞. 29 1704-1717

Gulvady,.福赛斯，我. 特纳，C.E. (2019) Hic-5 Regulates Src-induced Invadopodia Rosette Formation and Organization. 摩尔. 医学杂志. 细胞. 30 1298-1313.

徐,W.Gulvady,.C.格列兹尼，G.J.奥尔森，E.C. 特纳，C.E. (2019) Paxillin-dependent Microtubule Acetylation Regulates Apical-Basal Polarity in Mammary Gland Morphogenesis. 发展. 146 dev174367

Vohnoutka R.B.Gulvady,.C.格列兹尼，G.J K.汉德尔曼，S.K.塞克斯顿，J.Z. 特纳，C.E. (2019) The Focal Adhesion Scaffold Protein Hic-5 Regulates Vimentin Organization in Fibroblasts. 摩尔. 医学杂志. 细胞 30 3037-3056.

Complete List of Published Work in My Bibliography: