M赛义德谢赫，医学博士，博士

研究抽象

癌症生物学和治疗学

研究 activities are focused on the development of tumor markers and targets for cancer therapy. Work is also going on to elucidate the molecular mechanisms regulating cell death and survival signaling in normal and cancer cells to better understand the processes of cancer development and progression, 并发展出新颖的, more efficacious and less toxic anticancer agents. 研究 is also focused on cellular responses to genotoxic, ER and metabolic stresses.

选定的出版物

何，Q，罗，X，黄，Y，谢赫，MS. Apo2L/TRAIL differentially modulates the apoptotic effects of sulindac and a COX-2 selective non-steroidal anti-inflammatory agent in Bax-deficient cells. 中华肿瘤杂志，2002,21 (2):362 - 364.

罗欣，黄颖，谢赫MS. Cloning and characterization of a novel gene (PDRG) that is differentially regulated by p53 and ultraviolet radiation. 中华肿瘤杂志，2003,22 (2):747 - 757.

何强，黄颖，谢赫MS. Bax deficiency affects caspase 2 activation during ultraviolet radiation-induced apoptosis. 中国生物医学工程杂志，2004,23 (3):521 - 525.

谢赫MS及黄Y. Death receptors as targets of cancer therapeutics. 中国肿瘤防治杂志，2004,4 (4):397 - 3104.

何强，黄颖，谢赫MS. Proteasome inhibitor MG132 upregulates death receptor 5 and cooperates with Apo2L/TRAIL to induce apoptosis in Bax-proficient and -deficient cells. 中国生物医学工程杂志，2004,23 (3):554- 558.

何琦，黄燕，谢赫. Cyclooxygenase-2 interacts with p53 and interferes with p53-dependent transcription and apoptosis. 中华肿瘤杂志，2005,24 (4):334 - 344.

罗鑫，何强，黄燕，谢赫MS. Transcriptional upregulation of PUMA modulates endoplasmic reticulum calcium pool depletion-induced apoptosis via Bax activation. 细胞死亡杂志，12:1310-1318,2005.

科克兰,CA, Luo, X他，Q, Jiang, C，黄，Y and 酋长,米S. Genotoxic and endoplasmic reticulum stresses differentially regulate TRB3 expression. 癌症生物学 & 中华医学杂志，2005,4:1063-1067.

罗鑫，何强，黄燕，谢赫，MS. Cloning and characterization of a p53 and DNA damage down-regulated gene PIQ that codes for a novel calmodulin-binding IQ motif protein and is upregulated in gastrointestinal cancers. 中国生物医学工程杂志，25 (5):725- 733,2005.

柯克兰CA，黄毅，谢赫MS. The regulation of energy generating metabolic pathways by p53. 癌症生物学. 5:1610-1613, 2006.

黄旸，谢赫MS. TRAIL death receptors and cancer therapeutics. 苹果制药公司., 24:284-289, 2007.

荣荣，蒋丽丽，谢赫MS，黄勇. Mitotic kinase Aurora-A phosphorylates RASSF1A and modulates RASSF1A-mediated microtubule interaction and M-phase cell cycle regulation. 中国生物医学工程杂志，2006,26 (6):779 - 779.

黄勇，金伟，谢赫. RBEL1 is a novel gene that encodes a nucleo-cytoplasmic Ras superfamily GTP-binding protein and is overexpressed in breast cancer. 生物化学., 282:37640-37649, 2007.

他问, 罗X, 金女士, 黄Y, Reddy MVR, Reddy EP, 谢赫女士. Celecoxib and a novel COX-2 inhibitor ON09310 upregulate Death Receptor 5 expression via GADD153/CHOP. 中华肿瘤杂志，2008,27 (2):526 - 526.

Corcoran CA, 他问, Ponnusamy S, Ogretmen B, 黄Y and 谢赫女士. Neutral sphingomyelinase-3 (nSMase3) is DNA damage and non-genotoxic stress regulated gene that is deregulated in human malignancies.摩尔·巨蟹座., 6:795-807, 2008.

Montalbano J.，刘，K. 酋长,米.S.，黄，Y. Identification and characterization of RBEL1 subfamily of GTPases in the Ras Superfamily involved in cell growth regulation. J. 临床生物化学., 284:18129-18142, 2009.

施,J.他，Q.，安，J.，孙华，黄，杨.谢赫，M.S. Sulindac sulfide differentially induces apoptosis in Smac-proficient and –deficient human colon cancer cells. 摩尔. 细胞. 杂志., 1:92-97, 2009.

科克兰,C.A，蒙塔巴诺，J.Sun, H.他，Q.，黄，Y.谢赫，M.S. Identification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domains. J. 临床生物化学., 284:21955-21970, 2009.

江L, 罗X, 施J, 太阳H, Sun Q, 谢赫女士，黄毅. PDRG1, a novel tumor marker for multiple malignancies that is selectively regulated by genotoxic stress. 中华肿瘤杂志，2011 (11):567- 573.

蒋磊，荣荣，谢赫MS，黄勇. Cullin-4A•DNA damage-binding protein 1 E3 ligase complex targets tumor suppressor RASSF1A for degradation during mitosis. 中国生物医学工程学报，2011,26 (6):971- 978.

一个J, 施J, 他问, 他K, 刘Y, 黄旸，谢赫MS. CHCM1 / CHCHD6, novel mitochondrial protein linked to regulation of mitofilin and mitochondrial cristae morphology. 中国生物医学工程学报，2012,27 (2):444 - 444.

太阳H, 江L, 罗X, 金女士, 他问, 一个J, 他K, 施J, 荣R, 苏W, Lucchesi C, 刘Y, 谢赫女士，黄毅. Potential tumor-suppressive role of monoglyceride lipase in human colorectal cancer. 中国生物医学工程杂志，2013,32 (2):334 - 341.

Babbar M, 黄Y, 一个J, Landas SK, 谢赫女士. CHTM1, a novel metabolic marker deregulated in human malignancies. 致癌基因. 2018年1月26日. doi: 10.1038/s41388-017-0051-9.

Liu R, Wang X, Curtiss C, Landas S, 荣R, 谢赫女士，黄毅. Monoglyceride lipase gene knockout in mice leads to increased incidence of lung adenocarcinoma. 细胞死亡病. 2018年1月18日;9(2):36. doi: 10.1038/s41419-017-0188-z.

Babbar M, 黄Y, Curtiss CM, 谢赫女士. CHTM1 regulates cancer cell sensitivity to metabolic stress via p38-AIF1 pathway. [J]中国医学杂志. 2019年6月20日;38(1):271. doi: 10.1186/s13046-019-1253-5.

帕特尔H，谢赫MS，黄颖. ECRG2, a novel transcriptional target of p53, modulates cancer cell sensitivity to DNA damage. 细胞死亡病. 2020年7月17日;11(7):543. doi: 10.1038/s41419-020-2728-1.

Liu R, Wang X, Curtiss C, 谢赫女士，黄毅. Monoglyceride lipase mediates tumor-suppressive effects by promoting degradation of X-linked inhibitor of apoptosis protein. 细胞死亡不同. 2020年10月,27 (10):2888 - 2903. doi: 10.1038/s41418-020-0549-5.

Khayam AU, Patel H, Faiola NA, Figueroa Milla AE, Dilshad E, Mirza B, 黄旸，谢赫MS. Quinovic acid purified from medicinal plant Fagonia indica mediates anticancer effects via death receptor 5. 摩尔细胞生物化学. 2020年11月,474 (2):159 - 169. doi: 10.1007/s11010-020-03841-4.

谢赫女士，黄毅. Antibody-drug Conjugates for Breast Cancer Treatment. 最近的抗肿瘤药物发现. 2022;18(2):108-113. doi: 10.2174/1574892817666220729121205.